A LabVIEW-based electrical bioimpedance spectroscopic data interpreter (LEBISDI) for biological tissue impedance analysis and equivalent circuit modelling

Tushar Kanti Bera, J. Nagaraju, Gilles Lubineau

Abstract


Under an alternating electrical signal, biological tissues produce a complex electrical bioimpedance that is a function of tissue composition and applied signal frequencies. By studying the bioimpedance spectra of biological tissues over a wide range of frequencies, we can noninvasively probe the physiological properties of these tissues to detect possible pathological conditions. Electrical impedance spectroscopy can provide the spectra that are needed to calculate impedance parameters within a wide range of frequencies. Before impedance parameters can be calculated and tissue information extracted, impedance spectra should be processed and analyzed by a dedicated software program. National Instruments (NI) Inc. offers LabVIEW, a fast, portable, robust, user-friendly platform for designing data-analyzing software. We developed a LabVIEW-based electrical bioimpedance spectroscopic data interpreter (LEBISDI) to analyze the electrical impedance data for tissue characterization in medical, biomedical and biological applications. Here, we test, calibrate and evaluate the performance of LEBISDI on the impedance data obtained from simulation studies, electronic circuit element combinations as well as various biological tissues. We analyze the Nyquist plots obtained from the electrical impedance spectroscopy (EIS) measurements and compare the equivalent circuit parameters calculated by LEBISDI with the corresponding original circuit parameters to assess the accuracy of the program developed. Calibration studies show that LEBISDI accurately interpreted simulated and circuit-element data. Furthermore, results obtained from biological tissues show that LEBISDI successfully interpreted bioimpedance data and estimates of capacitance and resistance data. Finally, LEBISDI efficiently calculated and analyzed variation in bioimpedance parameters of different tissue compositions, health and temperatures. LEBISDI can also be used for human tissue impedance analysis for electrical impedance-based biopsy or cancer diagnosis.

Keywords


Electrical Bioimpedance, Electrical Impedance Spectroscopy (EIS), LabVIEW-Based Electrical Bioimpedance Spectroscopic Data Interpreter (LEBISDI), Curve Fitting, Nyquist Plots, Equivalent Circuit Modelling

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DOI: http://dx.doi.org/10.5617/jeb.2978